Publications

Abad, M. A., J. G. Ruppert, L. Buzuk, M. Wear, J. Zou, K. M. Webb, D. A. Kelly, P. Voigt, J. Rappsilber, W. C. Earnshaw and A. A. Jeyaprakash. (2019). Borealin-Nucleosome Interaction Secures Chromosome Association of the Chromosomal Passenger complex. J. Cell Biol. in press. PMID: 31570499; DOI: 10.1083/jcb.201905040. FREE ARTICLE 

Papini, D., X. Fant, H. Ogawa, N. Desban, K. Samejima, O. Feizbakhsh, B. Askin, T. Ly, W.C. Earnshaw & S. Ruchaud. (2019). Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1. J. Cell Sci. 132: jcs234401 equal corresponding authors. PMID: 31601613; DOI: 10.1242/jcs.234401. FREE ARTICLE

Liskovykh, M., N.V. Goncharov, N. Petrov, V. Aksenova, G. Pegoraro, L.L. Ozbun, W.C. Reinhold, S. Varma, M. Dasso, V. Kumeiko, H. Masumoto, W.C. Earnshaw, V. Larionov and N. Kouprina. (2019). A novel assay to screen siRNA libraries identifies protein kinases as required for chromosome transmission. Genome Res. 29:1719-1732 PMID: 31515286; PMC6771407; DOI: 10.1101/gr.254276.119. FREE ARTICLE

Remnant L., D.G. Booth, G. Vargiu, C. Spanos, A.R.W. Kerr, W.C. Earnshaw. (2019). In vitro BioID: Mapping the CENP-A Micro-Environment with high temporal and spatial resolution. Mol. Biol. Cell  30:1314-1325.  PMID: 30892990; PMC6724601; DOI: 10.1091/mbc.E18-12-0799. FREE ARTICLE

Ohzeki, J., V. Larionov, W.C. Earnshaw & H. Masumoto. (2019). De novo formation and epigenetic maintenance of centromere chromatin. Curr. Opin. Cell Biol 58:15-25. PMID: 30654232; PMC6626702; DOI: 10.1016/j.ceb.2018.12.004. FREE ARTICLE

Rata, S. M.F. Suarez Peredo Rodriguez, S. Joseph, N. Peter, F.E. Iturra, F. Yang, A. Madzvamuse, J.G. Ruppert, K. Samejima, M. Platani, M. Alvarez-Fernandez, M. Malumbres, W.C. Earnshaw, B. Novak & H. Hochegger. (2018). Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells Curr Biol. 28: 3824–3832. PMID: 30449668; PMC6287978; DOI: 10.1016/j.cub.2018.09.059. See also: M.L. Goldberg, (2018) Cell Cycle: Abrogating Interphase/M Phase Bistability Curr. Biol. 28, R1335–R1355. FREE ARTICLE

Lee, H.S.*, M. Carmena*, M. Liskovykh, E. Peat, J.H. Kim, M. Oshimura, H. Masumoto, M.P. Teulade-Fichou, Y. Pommier, W.C. Earnshaw, V. Larionov & N. Kouprina. (2018). *equal first authors. Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy. Cancer Res. 78: 8 6282-6296. PMID: 30166419; PMC6214708; DOI: 10.1158/0008-5472.CAN-18-0894. FREE ARTICLE 

Kouprina N., N. Petrov, O. Molina, M. Liskovykh, E. Pesenti, J.I. Ohzeki, H. Masumoto, W.C. Earnshaw & V. Larionov. (2018). Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies. ACS Synth Biol. 7: 1974-1989. PMID: 30075081; PMC6154217; DOI: 10.1021/acssynbio.8b00230. FREE ARTICLE

Saldivar, J.C., S. Hamperl, M.J. Bocek, M. Chung, T.E. Bass, F. Cisneros-Soberanis, K. Samejima, L. Xie, J.R. Paulson, W.C. Earnshaw, D. Cortez, T. Meyer and K.A. Cimprich. (2018). An intrinsic S/G2 checkpoint enforced by ATR. Science 361:806-810. PMID: 30139873; PMC6365305; DOI: 10.1126/science.aap9346. (Faculty of 1000)  FREE ARTICLE

Platani M., I. Samejima, K. Samejima, M.T. Kanemaki and W.C. Earnshaw. (2018). Seh1 targets GATOR2 and Nup153 to mitotic chromosomes J. Cell Science, 131: jcs213140. PMID: 29618633; PMC29618633; DOI: 10.1242/jcs.213140.  See also: Linking mTOR signalling to mitosis – the role of Seh1. J Cell Sci 2018 131: e0901 FREE ARTICLE

Pesenti E., N. Kouprina, M. Liskovykh, J. Aurich-Costa, V. Larionov, H. Masumoto, W.C. Earnshaw and O. Molina. (2018). Generation of a synthetic human chromosome with two centromeric domains for advanced epigenetic engineering studies. ACS Synthetic Biology, 20: 1116-1130. equal corresponding authors. PMID: 29565577; PMC: 5951608; DOI: 10.1021/acssynbio.8b00018. FREE ARTICLE

Combes G., H. Barysz, C. Garand, L. Gama Braga, I. Alharbi, P. Thebault, L. Murakami, D.P. Bryne, S. Stankovic, P.A. Eyers, V.M. Bolanos-Garcia, W.C. Earnshaw, J. Maciejowski, P.V. Jallepalli and S. Elowe. (2018). Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint.  Curr Biol. 28: 872-883. PMID: 29502948; PMC5863767; DOI: 10.1016/j.cub.2018.02.002. FREE ARTICLE

Ladds M.J.G.W.,  I.M.M. van Leeuwen, C.J. Drummond, S. Chu, A.R. Healy, G. Popova, A.P. Fernández, T. Mollick, S. Darekar, S.K. Sedimbi, M. Nekulova, M.C.C. Sachweh, J. Campbell, M. Higgins, C. Tuck, M. Popa, M.M. Safont, P. Gelebar, Z. Fandalyuk, A.M. Thompson, R. Svensson, A.-L. Gustavsson, L. Johansson, K. Färnegårdh, U. Yngve, A. Saleh, M. Haraldsson, A.C.A. D’Hollander, M. Franco, Y. Zhao, M. Håkansson, B. Walse, K. Larsson, E.M. Peat, V. Pelechano, J. Lunec, B. Vojtesek, M. Carmena, W.C. Earnshaw, A.R. McCarthy, N.J. Westwood, M. Arsenian-Henriksson, D.P. Lane, R. Bhatia, E. McCormack and S. Laín (2018). A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.  NATURE COMM. 9:1107. PMID: 29549331; PMC5856786; DOI: 10.1038/s41467-018-03441-3. FREE ARTICLE

Ruppert J.G., K. Samejima, M. Platani, O. Molina, H. Kimura, A.A. Jeyaprakash, S. Ohta and W.C. Earnshaw. (2018). HP1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry. EMBO J. 37, e97677. PMID: 29467217; PMC5852645; DOI: 0.15252/embj.201797677. FREE ARTICLE

Gibcus, J.H.*, K. Samejima*, A. Goloborodko*, I. Samejima, N. Naumova, J. Nuebler, M. Kanemaki, L. Xie, J.R. Paulson, W.C. Earnshaw, L.A. Mirny, J. Dekker. (2018). A pathway for mitotic chromosome formation. Science 9:359. *equal first authors. equal corresponding authors. PMID: 29348367; PMC5924687; DOI: 10.1126/science.aao6135. Co-communicating author, See also: Nat. Rev. Cell Biol. 19:139 A stairway to mitotic chromosome assembly (DOI: 10.1038/nrm.2018.13); See also: Quanta Magazine – https://www.quantamagazine.org/how-cells-pack-tangled-dna-into-neat-chromosomes-20180222/ (Faculty of 1000) FREE ARTICLE

Samejima K., D. Booth, H. Ogawa, J. Paulson, L. Xie, C. Watson, M. Platani, M.T. Kanemaki and W.C. Earnshaw. (2018). Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis. J. Cell Science, 131. pii: jcs210187. PMID: 29361541; PMC5868952; DOI: 10.1242/jcs.210187; FREE ARTICLE

Lee N.C.O, J.H. Kim, N. Petrov, H.S. Lee, H. Masumoto, W.C. Earnshaw, V. Larionov and N. Kouprina (2018). Method to assemble genomic DNA fragments or genes on Human Artificial Chromosome with regulated kinetochore using a multi-integrase system. ACS Synth Biol. 7:63-74. PMID: 28799737; PMC5778389;  DOI: 10.1021/acssynbio.7b00209; FREE ARTICLE

Samejima I. & W.C. Earnshaw. (2018). Isolation of mitotic chromosomes from vertebrate cells and characterization of their proteome by mass spectrometry. Methods Cell Biol. 144: 329-348: PMID: 29804675; DOI: 10.1016/bs.mcb.2018.03.021. ARTICLE

Booth, D.G. and W.C. Earnshaw (2017) Ki-67 and the Chromosome Periphery Compartment in Mitosis. Trends Cell Biol. 27:906-916. PMID: 28838621DOI: 10.1016/j.tcb.2017.08.001; ARTICLE

Molina, O., N. Kouprina, H. Masumoto, V. Larionov and W.C. Earnshaw (2017). Using human artificial chromosomes to study centromere assembly and function. Chromosoma 126:559-575. PMID: 28688039DOI: 10.1007/s00412-017-0633-x; ARTICLE

Zhiteneva, A., J.J. Bonfiglio, A. Makarov, T. Colby, P. Vagnarelli, E.C. Schirmer, I. Matic and W.C Earnshaw. (2017). Mitotic post-translational modifications of histones promote chromatin compaction in vitro. Open Biol. 7, pii: 170076. PMID: 28903997; PMC5627050;  DOI: 10.1098/rsob.170076; FREE ARTICLE

Spiller, F., B. Medina-Pritchard, M.A. Abad, M. Wear, O. Molina, W.C. Earnshaw and A.A. Jeyaprakashsh. (2017) Molecular Basis for Cdk1 Regulated Timing of Mis18 Complex Assembly and CENP-A Deposition. EMBO Repts. 18: 894-905. PMID: 28377371; PMC5452045;  DOI: 10.15252/embr.201643564; FREE ARTICLE

Vargiu, G., A.A. Makarov, J. Allan, T. Fukagawa, D.G. Booth and W.C. Earnshaw. (2017) Stepwise unfolding supports a subunit model for vertebrate kinetochores. Proc. Natl. Acad. Sci. U.S.A. 114: 3133-3138. PMID: 28265097; PMC5373359;  DOI: 10.1073/pnas.1614145114; FREE ARTICLE

Montaño-Gutierrez, L.F., S. Ohta, G. Kustatscher, William C. Earnshaw, Juri Rappsilber. (2017). Nano Random Forests to mine protein complexes and their relationships in quantitative proteomics data.  Mol. Biol. Cell.  15:2802-2818. PMID: 28057767; PMC5328625;  DOI: 10.1091/mbc.E16-06-0370; FREE ARTICLE

Molina O., M. Carmena, I.E. Maudlin & William C. Earnshaw. (2016). PREditOR: a synthetic biology approach to removing heterochromatin from cells. Chromosome Res. 24:495-509. PMID: 27924426; PMC5167778; DOI: 10.1007/s10577-016-9539-3; FREE ARTICLE

Booth D.G., A.J. Beckett, O. Molina, I. Samejima, H. Masumoto, N. Kouprina, V. Larionov, I.A. Prior and W.C. Earnshaw. (2016). 3D-CLEM reveals that a major portion of mitotic chromosomes is not chromatin Mol. Cell. 64:790-802. PMID: 27840028; PMC4974353; DOI: 10.1016/j.molcel.2016.10.009; FREE ARTICLE

Molina O., G. Vargiu, M.A. Abad, A. Zhiteneva, J. Arulanandam, H. Masumoto, N. Kouprina, V. Larionov and W.C. Earnshaw. (2016) Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance. Nature Commun. 7:13334. PMID: 27841270; PMC5114538; DOI: 10.1038/ncomms13334. FREE ARTICLE

Ohta S., L.F. Montaño, F. de L. Alves., H. Ogawa, I. Toramoto, N. Sato, C.G. Morrison, S. Takeda, D.F. Hudson, J. Rappsilber and W.C. Earnshaw. (2016). Proteomics analysis with a nano Random Forest approach reveals novel functional interactions regulated by SMC complexes on mitotic chromosomes. Mol. Cell. Prot. 28:673-680. PMID: 27231315; PMC4974353; DOI: 10.1074/mcp.M116.057885; FREE ARTICLE

Ohzeki J., N.Shono, K. Otake, N.M.C. Martins, K. Kugou, H. Kimura, T. Nagase, V. Larionov, W.C. Earnshaw and H. Masumoto. (2016). KAT7/HBO1/MYST2 regulates CENP-A chromatin assembly by antagonizing Suv39h1-mediated centromere inactivation. Dev. Cell. 37:413-27. PMID: 27270040; PMC4906249; DOI: 10.1016/j.devcel.2016.05.006; FREE ARTICLE

Kim J.H., H.S. Lee, N.C. Lee, N.V. Goncharov, V. Kumeiko, H. Masumoto, W.C. Earnshaw, N. Kouprina, V. Larionov (2016). Development of a novel HAC-based “gain of signal” quantitative assay for measuring chromosome instability (CIN) in cancer cells.  Oncotarget 7:14841-14856. PMID: 26943579; PMC4924756; DOI: 10.18632/oncotarget.7854; FREE ARTICLE

Wood, L, D.G. Booth, G. Vargiu, S. Ohta, F. deLima Alves, K. Samejima, T. Fukagawa, J. Rappsilber and W.C. Earnshaw. (2016). Auxin/AID versus conventional knockouts: distinguishing the roles of CENP-T/W in mitotic kinetochore assembly and stability. Open Biology 6: 150230. PMID: 26791246; PMC4736828; DOI: 10.1098/rsob.150230; FREE ARTICLE

Samejima I., M. Platani and W.C. Earnshaw (2015). Use of Mass Spectrometry to Study the Centromere and Kinetochore. Prog. Mol. Subcell. Biol. 56:3-27. PMID: 28840231; PMC4646952; DOI: 10.1007/978-3-319-58592-5_1. ARTICLE

Carmena, M., W.C. Earnshaw and D.M. Glover (2015). The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic. Front. Cell Dev. Biol. 3: 73. PMID: 26636082; PMC4646952; DOI: 10.3389/fcell.2015.00073; FREE ARTICLE

Earnshaw, W.C. (2015). Q&A: William Earnshaw. Curr. Biol. 25: R483-R489. PMID: 26280061 DOI: 10.1016/j.cub.2015.03.003. FREE ARTICLE

Martins, N.M.C., J. Bergmann, N. Shono, H. Kimura, V.Larionov, H. Masumoto and W.C. Earnshaw. (2015). Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3. Mol. Biol. Cell. 27:177-196. PMID: 26564795; PMC4694756;  DOI: 10.1091/mbc.E15-08-0605; FREE ARTICLE   

Samejima, I.  C. Spanos, F. de Lima Alves, T. Hori, M. Perpelescu, J. Zou, J. Rappsilber, T. Fukagawa and W.C. Earnshaw. (2015). Whole proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore. J. Cell Biol. 211:1141-1156. PMID: 26668330; PMC4687880; DOI: 10.1083/jcb.201508072. (featured in “In This Issue” – J. Cell Biol. 211:1098; and “Research Highlights” Nature Reviews Mol. Cell Biol. 17:66, 2016, doi:10.1038/nrm.2015.30) FREE ARTICLE

Shono, N., J. Ohzeki, K. Otake, N.M.C Martins, T. Nagase, H. Kimura, V. Larionov, W.C. Earnshaw, and H. Masumoto (2015). CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly. J. Cell Sci. 128: 4572-4587. PMID: 26527398; PMC4696500; DOI: 10.1242/jcs.180786; FREE ARTICLE  

González-Loyola, A., G. Fernández-Miranda, M. Trakala, D. Partida, K. Samejima, H. Ogawa, M. Cañamero, A. de Martino, Á. Martínez-Ramírez, G. de Cárcer, I. Pérez de Castro, W.C. Earnshaw & M. Malumbres (2015). Aurora B overexpression causes aneuploidy and p21Cip1 repression during tumor development. Mol. Cell. Biol. 35: 3566-3578. PMID: 26240282; PMC4573715;  DOI: 10.1128/MCB.01286-14; FREE ARTICLE

Samejima, K, M. Platani, M. Wolny, H. Ogawa, G. Vargiu, P.J. Knight, M. Peckham M & W.C. Earnshaw. (2015). The INCENP Coil is a Single Alpha Helical (SAH) Domain that Binds Directly to Microtubules and is Important for CPC Localization and Function in Mitosis. J. Biol. Chem. 290: 21460-21472. PMID: 26175154; PMC4571873; DOI: 10.1074/jbc.M115.645317; FREE ARTICLE

Platani, M., L. Trinkle-Mulcahy, M. Porter, A.A. Jeyaprakash and W.C. Earnshaw. (2015). Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes. J. Cell Biol. 210: 45-62. PMID: 26124292; PMC4494011; DOI: 10.1083/jcb.201410001; FREE ARTICLE

Papini, D., L. Langemeyer, M.A. Abad, A. Kerr, I. Samejima, P.A. Eyers, A.A. Jeyaprakash, J.M.G. Higgins, F.A. Barr and W.C. Earnshaw. (2015). TD-60 links RalA GTPase function to the CPC in mitosis.  Nature Comms. 6: 7678. PMID: 26158537; PMC4510650; DOI:10.1038/ncomms8678; FREE ARTICLE

Earnshaw WC. (2015). Discovering centromere proteins: from cold white hands to the A, B, C of CENPs. Nat. Rev. Mol. Cell Biol. 16: 443-449. PMID: 25991376; DOI: 10.1038/nrm4001. ARTICLE

Kononenko, A., N.C.O. Lee, M. Liskovykh, H. Masumoto, W.C. Earnshaw, V. Larionov, N. Kouprina, (2014) Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette.  Nucleic Acids Res. 43: e57. PMID: 25712097; PMC4482055; DOI: doi:10.1093/nar/gkv124; FREE ARTICLE

Carvalho A.X., H. Maiato, A. Maia, S. Ribeiro, P. Pontes, W. Bickmore, W.C. Earnshaw, and C. Sambade. (2015) Reed-Sternberg cells form by abscission failure in the presence of functional Aurora B kinase.  PLoS One 10: e0124629. PMID: 25933052; PMC4416800; DOI: 10.1371/journal.pone.0124629; FREE ARTICLE

Ohta, S., L. Wood, I. Toramoto, K.-I. Yagyu, T. Fukagawa, and W.C. Earnshaw. (2015). CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly Mol. Biol. Cell 26:1225-1237. PMID: 25657325; PMC4454171; DOI: 10.1091/mbc.E14-09-1366; FREE ARTICLE

Barysz, H., J.H. Kim., Z.A. Chen, D.F. Hudson, J. Rappsilber, D.L. Gerloff and W.C. Earnshaw. (2015). 3D topology of the SMC2/SMC4 sub-complex from chicken condensin I revealed by cross-linking and molecular modeling. Open Biol. 5: 150005. PMID: 25716199; PMC4345284; DOI: 10.1098/rsob.150005; FREE ARTICLE

Ohzeki J, Larionov V, Earnshaw WC, Masumoto H. (2015). Genetic and epigenetic regulation of centromeres: a look at HAC formation. Chromosome Res. 23:87-103. PMID: 25682171; Identifier not found in PMC; DOI: 10.1007/s10577-015-9470-z. ARTICLE

Castonguay, E., S.A. White, A. Kagansky, D.J. St. Cyr, A.G. Castillo, C. Brugger, R. White, C. Bonilla, M. Spitzer, W.C. Earnshaw, T. Schalch, K. Ekwall, M. Tyers and R.C. Allshire. (2014). Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing. Mol. Cell. Biol. 15:662-674. PMID: 25487573; PMC4301722; DOI: 10.1128/MCB.01102-14; FREE ARTICLE

Kononenko, A.V., R. Bansal, N.C.O Lee, B.R. Grimes, H. Masumoto, W.C. Earnshaw, V. Larionov, N. Kouprina. (2014). A portable BRCA1-HAC module for analysis of BRCA1 tumor suppressor function. Nucleic Acids Res. (2014). PMID: 25260588; PMC4245969; DOI: 10.1093/nar/gku870; FREE ARTICLE  

Samejima K., H. Ogawa, A.V. Ageichik, K.L. Peterson, S.H. Kaufmann, M.T. Kanemaki and W.C. Earnshaw. (2014) A cell suicide module: Auxin-induced rapid degradation of Inhibitor of Caspase Activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation and cell death. J. Biol. Chem. 289: 31617-31623. PMID: 25248749; PMC4223357; DOI: 10.1074/jbc.M114.583542; (Faculty of 1000) FREE ARTICLE  

Gohard, F.H., D. St-Cyr, M. Tyers and W.C. Earnshaw. (2014). Targeting the INCENP INbox: Aurora B interaction to inhibit CPC activity in vivo. Open Biol. 4: 140163. PMID: 25392451; PMC4248066; DOI: 10.1098/rsob.140163; FREE ARTICLE

Carmena, M., M.O. Lombardia, H. Ogawa and W.C. Earnshaw. (2014). Polo kinase regulates the localization and activity of the CPC in meiosis and mitosis in Drosophila melanogaster. Open Biol. 4:140162. PMID: 25376909; PMC4248065; DOI: 10.1098/rsob.140162; FREE ARTICLE

Erliandri, I., F. Haiqing, M. Nakano, J.-H. Kim, K.H. Miga, M. Liskovykh, W.C. Earnshaw, H. Masumoto, N. Kouprina, M.I. Aladjem, Vladimir Larionov. (2015). Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome. Nucleic Acids Res. 42:11502-11516. PMID: 25228468; PMC4191410;  DOI: 10.1093/nar/gku835; FREE ARTICLE

Fukagawa, T. and W.C. Earnshaw. (2014). Quick Guide: Neocentromeres. Curr. Biol. 24:R946-R947. PMID: 25291631; DOI: 10.1016/j.cub.2014.08.032. FREE ARTICLE

Fukagawa, T. and W.C. Earnshaw. (2014). The centromere: Chromatin foundation for the kinetochore machinery. Dev. Cell 30:496-508. PMID: 25203206; PMC4160344; DOI: 10.1016/j.devcel.2014.08.016; FREE ARTICLE  

Hori, T. 7, W.-H. Shang, 7, A. Toyoda, S. Misu, N. Monma, K. Ikeo, O. Molina, G. Vargiu, A. Fujiyama, Hi. Kimura, W.C. Earnshaw, and T. Fukagawa. (2014) Histone H4 Lys 20 mono-methylation of the CENP-A nucleosome is essential for kinetochore assembly. Dev. Cell 29:740-749. PMID: 24960696; PMC4081567; DOI: 10.1016/j.devcel.2014.05.001; FREE ARTICLE  

Booth, D.G., M. Takagi, L. Sanchez-Pulido, E. Petfalski, G. Vargiu, K. Samejima, N. Imamoto, C.P. Ponting, D. Tollervey, W.C. Earnshaw and P. Vagnarelli (2014). Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery. eLife 3:e01641. equal corresponding authors. PMID: 24867636; PMC4032110; DOI: 10.7554/eLife.01641; FREE ARTICLE  

Kouprina, N. A.N. Tomilin, H. Masumoto, W.C. Earnshaw, Vladimir Larionov. (2013). Human artificial chromosomes or HAC-based gene delivery vectors for biomedicine and biotechnology. Expert Opinion on Drug Delivery. 11:517-535. PMID: 24479793; DOI: 10.1517/17425247.2014.882314 ARTICLE

Ribeiro, S.A., P. Vagnarelli and W.C. Earnshaw. (2014) DNA content of a functioning chicken kinetochore. Chromosome Res. 22:7-13. PMID: 24633498;  PMC4067537; DOI: 10.1007/s10577-014-9410-3; FREE ARTICLE  

Earnshaw, W.C. (2013). Deducing protein function by forensic integrative cell biology. PLoS Biol. 11, e1001742 PMID: 24358025; PMC3866084; DOI: 10.1371/journal.pbio; FREE ARTICLE

Kim, J.H., T. Zhang, N.C. Wong, N. Davidson, J. Maksimovic, A. Oshlack, W.C. Earnshaw, P. Kalitsis & D.F. Hudson (2013). Condensin I associates with gene promoters, centromeres and telomeres in vertebrates. Nature Commun. 4:2537. PMID: 24088984; PMC4038772; DOI: 10.1038/ncomms3537; FREE ARTICLE

Lee, N.C.O., A. Kononenko, H.-S. Lee, E.N. Tolkunova, M.A. Liskovykh, H. Masumoto, W.C. Earnshaw, A.N. Tomilin, V. Larionov and N. Kouprina. (2013). Protecting a transgene expression from the HAC-based vector by different chromatin insulators. Cell Mol. Life Sci. 70:3723-3737. PMID: 23677492; PMC3771377; DOI: 10.1007/s00018-013-1362-9; FREE ARTICLE

Gohard, F.H., A.A. Zhiteneva, Alisa A & W.C. Earnshaw. (2014) Centromeres. In: eLS 2014, John Wiley & Sons Ltd: Chichester http://www.els.net/. DOI: 10.1002/9780470015902.a0005785.pub2  ARTICLE

Earnshaw, W.C. & D.W. Cleveland. (2013). CENP-A and the CENP Nomenclature: Response to Talbert and Henikoff. Trends Genet. 29:500-502. PMID: 223910159; DOI: 10.1016/j.tig.2013.06.008 ARTICLE

Lee, H.-S., N.C.O. Lee, B.R. Grimes, A. Samoshkin, A.V. Kononenko, H. Masumoto, W.C. Earnshaw, N. Kouprina and V. Larionov (2013). A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells. BMC Cancer, 13:252. PMID: 23694679; PMC3671967; DOI: 10.1186/1471-2407-13-252; FREE ARTICLE

Kononenko A.V., N.C. Lee, W.C. Earnshaw, N. Kouprina and V. Larionov. (2013). Re-engineering an alphoidtetO-HAC-based vector to enable high-throughput analyses of gene function. Nucleic Acids Res. 41:e107 PMID: 23558748; PMC3664798; DOI: 10.1093/nar/gkt205; FREE ARTICLE

Earnshaw, W.C., R.C. Allshire, B.E. Black, K. Bloom, B.R. Brinkley, W. Brown, I.M. Cheeseman, K.H.A. Choo, G.P. Copenhaver, J.G. DeLuca, A. Desai, S. Diekmann, S. Erhardt, M. Fitzgerald-Hayes, D. Foltz, T. Fukagawa, R. Gassmann, D.W. Gerlich, D.M. Glover, G.J. Gorbsky, S.C. Harrison, P. Heun, T. Hirota, L.E.T. Jansen, G. Karpen, G.J.P. Kops, M.A. Lampson, S.M. Lens, A. Losada, K. Luger, H. Maiato, P.S. Maddox, R.L. Margolis, H. Masumoto, A.D. McAinsh, B.G. Mellone, P. Meraldi, A. Musacchio, K. Oegema, R.J. O’Neill, E.D. Salmon, K. Scott, A.F. Straight, P.T. Stukenberg, B.A. Sullivan, K.F. Sullivan, C.E. Sunkel, J.R. Swedlow, C.E. Walczak, P.E. Warburton, S. Westermann, H.F. Willard, L. Wordeman, M. Yanagida, T.J. Yen, K. Yoda and D.W. Cleveland. (2013). Esperanto for Histones: CENP-A, not CenH3, is the centromeric histone H3 variant Chromosome Res. 21:101-106. PMID: 23580138; PMC3627038; DOI: 10.1007/s10577-013-9347-y FREE ARTICLE

Kouprina N., W.C. Earnshaw, H. Masumoto and V. Larionov. (2012) A new generation of human artificial chromosomes for functional genomics and gene therapy. Cellular and Molecular Life Sciences 70:1135-1148. PMID: 22907415; PMC3522797; DOI: 10.1007/s00018-012-1113-3; FREE ARTICLE

Shang W-H, T. Hori, N.M.C. Martins, A. Toyoda, S. Misu, N. Monma, I. Hiratani, K. Maeshima, K. Ikeo, A. Fujiyama, H. Kimura, W.C. Earnshaw and T. Fukagawa. (2013). Chromosome engineering allows the efficient isolation of vertebrate neocentromeres. Dev. Cell 24:635-648. PMID: 23499358; PMC3925796; DOI: 10.1016/j.devcel.2013.02.009; (Faculty of 1000) FREE ARTICLE

Tachiwana, H., Y. Miya, N. Shono, J. Ohzeki, A. Osakabe, K. Otake, V. Larionov., W.C. Earnshaw, H. Kimura, H. Masumoto, and H. Kurumizaka. (2013). Nap1 regulates proper CENP-B binding to nucleosomes Nucleic Acids Res. 41:2869-2880 PMID: 23325853; PMC3597661; DOI: 10.1093/nar/gks1464; FREE ARTICLE

Kouprina N., A. Samoshkin, I. Erliandri, M. Nakano, H.-S. Lee, H. Fu, M.I. Aladjem, H. Masumoto, W.C. Earnshaw and V. Larionov. (2012) Organization of Synthetic Alphoid DNA Array in Human Artificial Chromosome (HAC) with a Conditional Centromere. ACS Synth. Biol. 1:590-601. PMID: 23411994; PMC3568986; DOI: 10.1021/sb3000436; ARTICLE

Carmena, M., M. Wheelock, H. Funabiki and W.C. Earnshaw. (2012). The Chromosomal Passenger Complex (CPC): From Easy Rider to the Godfather of Mitosis. Nature Revs. Mol. Cell Biol. 13:789-803. PMID: 23175282; PMC3729939; DOI: 10.1038/nrm3474; ARTICLE

Samejima, K., I. Samejima, P. Vagnarelli, H. Ogawa, G. Vargiu, D.A. Kelly, F. de Lima Alves, A. Kerr, L.C. Green, D.F. Hudson, S. Ohta, C.A. Cooke, C.J. Farr, J. Rappsilber, and W.C. Earnshaw. (2012). Mitotic chromosomes are compacted laterally by KIF4 and Condensin and axially by Topoisomerase IIα. J. Cell Biol.199:755-770. PMID: 23166350; PMC3514791; DOI: 10.1083/jcb.201202155 (featured in “In Focus” – J. Cell Biol. 199:715; and “Research Highlights” Nature Reviews Mol. Cell Biol. (2013) 14:2-4) (Faculty of 1000) FREE ARTICLE

Bergmann, J.H., N.M.C. Martins, V. Larionov, H. Masumoto & W.C. Earnshaw. (2012). HACking the centromere chromatin code: insights from human artificial chromosomes. Chromosome Res. 20:505-519. PMID: 22825423; DOI: 10.1007/s10577-012-9293-0 FREE ARTICLE

Ohzeki J., J.H. Bergmann, N. Kouprina, V.N. Noskov, M. Nakano, H. Kimura, W.C. Earnshaw, V. Larionov and H. Masumoto. (2012). Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly. The EMBO J. 31:2391-2402. PMID: 22473132; PMC3364751; DOI: 10.1038/emboj.2012.82; FREE ARTICLE

Green L.C., P. Kalitsis, T.M. Chang, M. Cipetic, J.H. Kim, O. Marshall, L. Turnbull, C.B. Whitchurch, P. Vagnarelli, K. Samejima, W.C Earnshaw, K.H.A. Choo, D.F. Hudson. (2012). Contrasting roles of Condensin I and II in mitotic chromosome formation. J. Cell Sci. 125:1591-1604. PMID: 22344259; PMC3336382; DOI: 10.1242/jcs.097790 FREE ARTICLE

Vagnarelli, P. & W.C. Earnshaw. (2012) Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly. Nucleus 3:1-5. PMID: 22555598; PMC3383568; DOI: 10.4161/nucl.3.2.19267; FREE ARTICLE

Bergmann J.H., J. Jakubsche, N.M. Martins, A. Kagansky, M. Nakano, H. Kimura, D.A. Kelly, B.M. Turner, H. Masumoto, V. Larionov and W.C. Earnshaw. (2012). Epigenetic Engineering: Histone hyper-acetylation is compatible with kinetochore structure and function. J. Cell Sci. 125:411-421. PMID: 22331359; PMC3283876; DOI: 10.1242/jcs.090639 (featured in “In This Issue”: J. Cell Sci. 125:e202 issue) FREE ARTICLE

Carmena M., X. Pinson, M. Platani, Z. Salloum, Z. Xu, A. Clark, F. MacIsaac, H. Ogawa, U. Eggert, D.M. Glover, V. Archambault, W.C. Earnshaw. (2012). The Chromosomal Passenger Complex Activates Polo Kinase at Centromeres. PLoS Biol. 10, e1001250 PMID: 22291575; PMC3265468; DOI: 10.1371/annotation/7832f573-e0d9-465f-b5d4-0ac1014b6112; FREE ARTICLE

Kim J.-H., A. Kononenko, I. Erliandri, T.-A. Kim, M. Nakano, Y. Iida, J. C. Barrett, M. Oshimura, H. Masumoto, W.C. Earnshaw, V. Larionov & N. Kouprina. (2011). Human Artificial Chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells. Proc. Nat. Acad. Sci. (USA) 108:20048-20053. PMID: 22123967; PMC3250132; DOI: 10.1073/pnas.1114483108; FREE ARTICLE

Flors C. and W.C. Earnshaw. (2011). Super-resolution fluorescence microscopy as a tool to study the nanoscale organization of chromosomes. Curr. Op. Chem. Biol. 15:838-844. PMID: 22098720; DOI: 10.1016/j.cbpa.2011.10.004 ARTICLE

Vagnarelli P., S. Ribeiro, L. Sennels, L. Sanchez-Pulido, F. de L. Alves, T. Verheyen, D.A. Kelly, C.P. Ponting, J. Rappsilber and W.C. Earnshaw. (2011). Repo-Man coordinates chromosomal reorganisation with nuclear envelope reassembly during mitotic exit. Dev. Cell 21: 328-342. PMID: 21820363; PMC3480639; DOI: 10.1016/j.devcel.2011.06.020 (featured in Nature Revs. Mol. Cell Biol. October issue) FREE ARTICLE

Bergmann J.H., M. Gomez Rodriguez, N.M.C. Martins, H. Kimura, D.A. Kelly, H. Masumoto, V. Larionov, L.E.T. Jansen and W.C. Earnshaw. (2011). Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore. The EMBO J. 30: 328-340. PMID: 21157429; PMC3025471; DOI: 10.1038/emboj.2010.329 (see also EMBO J. 30:233-234) FREE ARTICLE

Ohta S., J.-C. Bukowski-Wills, L. Wood, F. de L. Alves, Z.A. Chen, J. Rappsilber and W.C. Earnshaw. (2010). Proteomics of isolated mitotic chromosomes identifies the kinetochore protein Ska3/Rama1. Cold Spring Harbor Symp. Quant. Biol. 75:433-438 PMID: 21289047 ; DOI: 10.1101/sqb.2010.75.022 FREE ARTICLE

Ohta S., L. Wood, J.-C. Bukowski-Wills, J. Rappsilber and W.C. Earnshaw. (2010). Building mitotic chromosomes. Curr. Opin. Cell Biol. 23:114-121 PMID: 20974528; PMC3060342 DOI: 10.1016/j.ceb.2010.09.009; FREE ARTICLE

Fant X., K. Samejima, A. Carvalho, H. Ogawa, Z. Xu, Z. Yue, W.C. Earnshaw and S. Ruchaud (2010). Use of DT40 conditional knockout cell lines to study chromosomal passenger proteins function. Biochem. Soc. Trans. 38:1655-1659. equal corresponding authors PMID: 21118143; PMC3428912; DOI: 10.1042/BST0381655 FREE ARTICLE

Xu Z, P. Vagnarelli, H. Ogawa, K. Samejima, W.C. Earnshaw. (2010) Gradient of increasing Aurora B activity is required for cells to execute mitosis. J. Biol. Chem. 285: 40163-40170. PMID: 20956539; PMC3000998; DOI: 10.1074/jbc.M110.181545; FREE ARTICLE

Iida Y., J.-H. Kim, Y. Kazuki, H. Hoshiya, M. Takiguchi, M. Hayashi, I. Erliandri, H.-S. Lee, A. Samoshkin, H. Masumoto, W.C. Earnshaw, N. Kouprina, V. Larionov and M. Oshimura. (2010). Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression. DNA Research 17: 293-301. PMID: 20798231; PMC2955713; DOI: 10.1093/dnares/dsq020; FREE ARTICLE

Ohta S.*, J.-C. Bukowski-Wills*, L. Sanchez-Pulido, F. de L. Alves, L. Wood, Z.A. Chen, M. Platani, L. Fischer, D.F. Hudson, C.P. Ponting, T. Fukagawa, W.C. Earnshaw and J. Rappsilber. (2010). The protein composition of mitotic chromosomes determined using multi-classifier combinatorial proteomics. Cell 142: 810-821. *equal first authors. equal corresponding authors. PMID: 20813266; PMC2982257; DOI: 10.1016/j.cell.2010.07.047 (Faculty of 1000; see also Dev. Cell 19: 356-359; Nature Methods 7: 869; Biotechniqueshttp://www.biotechniques.com/news/biotechniquesNews/biotechniques-303722.html Science Dailyhttp://www.sciencedaily.com/releases/2010/09/100902121055.htm) FREE ARTICLE

Fernández-Miranda, I. Pérez de Castro, M. Carmena, C. Aguirre-Portolés, S. Ruchaud, X. Fant, G. Montoya, W.C. Earnshaw and M. Malumbres. (2010). SUMOylation modulates the function of Aurora-B kinase. J. Cell. Sci. 123: 2823-2833. PMID: 20663916; PMC2915883; DOI: 10.1242/jcs.065565; FREE ARTICLE

Patzlaff J.S., E. Terrenoire, B.M. Turner, W.C. Earnshaw and J.R. Paulson. (2010). Acetylation of core histones in response to HDAC inhibitors is diminished in mitotic HeLa cells. Exp. Cell Res. 316: 2123-2135. PMID: 20452346; PMC2938188; DOI: 10.1016/j.yexcr.2010.05.003; FREE ARTICLE

Ribeiro, S.A., P. Vagnarelli, Y. Dong, T. Hori, B.F. McEwen, T. Fukagawa, C. Flors and W.C. Earnshaw. (2010). A super-resolution map of the vertebrate kinetochore. Proc. Nat. Acad. Sci. (USA) 107: 10484-10489. PMID: 20483991; PMC2890832; DOI: 10.1073/pnas.1002325107; FREE ARTICLE

Mocciaro, A., E. Berdougo, E. Black, P. Vagnarelli, W.C. Earnshaw, D. Gillespie, P. Jallepalli, and E. Schiebel. (2010). Vertebrate cells deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. J. Cell Biol. 189: 631-639. PMID: 20479464; PMC2872905; DOI: 10.1083/jcb.200910057 (Faculty of 1000) FREE ACCESS